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Structural basis for CDK7 activation by MAT1 and Cyclin H
Cyclin-dependent kinase 7 (CDK7), Cyclin H, and the RING-finger protein MAT1 form the heterotrimeric CDK-activating kinase (CAK) complex which is vital for transcription and cell-cycle control. When associated with the general transcription factor II H (TFIIH) it activates RNA polymerase II by hyper...
Autores principales: | Peissert, Stefan, Schlosser, Andreas, Kendel, Rafaela, Kuper, Jochen, Kisker, Caroline |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604442/ https://www.ncbi.nlm.nih.gov/pubmed/33055219 http://dx.doi.org/10.1073/pnas.2010885117 |
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