Lactate Induces Cisplatin Resistance in S. cerevisiae through a Rad4p-Dependent Process

Cisplatin is a widely used antineoplastic agent that has DNA as the main target, though cellular resistance hampers its therapeutic efficacy. An emerging hallmark of cancer cells is their altered metabolism, characterized by increased glycolysis even under aerobic conditions, with increased lactate...

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Detalles Bibliográficos
Autores principales: Amaral, Leslie, Mendes, Filipa, Côrte-Real, Manuela, Sousa, Maria João, Chaves, Susana Rodrigues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604607/
https://www.ncbi.nlm.nih.gov/pubmed/33163143
http://dx.doi.org/10.1155/2020/4971525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604607/
https://www.ncbi.nlm.nih.gov/pubmed/33163143
http://dx.doi.org/10.1155/2020/4971525

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