Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction

Short telomeres are a principal defining feature of telomere biology disorders, such as dyskeratosis congenita (DC), for which there are no effective treatments. Here, we report that primary fibroblasts from DC patients and late generation telomerase knockout mice display lower nicotinamide adenine...

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Detalles Bibliográficos
Autores principales: Sun, Chongkui, Wang, Kun, Stock, Amanda J, Gong, Yi, Demarest, Tyler G, Yang, Beimeng, Giri, Neelam, Harrington, Lea, Alter, Blanche P, Savage, Sharon A, Bohr, Vilhelm A, Liu, Yie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604620/
https://www.ncbi.nlm.nih.gov/pubmed/32935380
http://dx.doi.org/10.15252/embj.2019103420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604620/
https://www.ncbi.nlm.nih.gov/pubmed/32935380
http://dx.doi.org/10.15252/embj.2019103420

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