Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura

Antibodies that develop in patients with immune thrombotic thrombocytopenic purpura commonly target the spacer epitope R568/F592/R660/Y661/Y665 (RFRYY) of ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13). In this study we present a detailed contribution of...

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Detalles Bibliográficos
Autores principales: Graça, Nuno A. G., Ercig, Bogac, Pereira, Leydi Carolina Velásquez, Kangro, Kadri, Kaijen, Paul, Nicolaes, Gerry A. F., Veyradier, Agnès, Coppo, Paul, Vanhoorelbeke, Karen, Männik, Andres, Voorberg, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604655/
https://www.ncbi.nlm.nih.gov/pubmed/33131251
http://dx.doi.org/10.3324/haematol.2019.226068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604655/
https://www.ncbi.nlm.nih.gov/pubmed/33131251
http://dx.doi.org/10.3324/haematol.2019.226068

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