Effect of gastric acid‐reducing agents on the pharmacokinetics and efficacy of lemborexant

Lemborexant is a dual orexin receptor antagonist approved for treating insomnia. As the solubility of lemborexant is pH‐sensitive, the impact of the gastric acid‐reducing agent (ARA), famotidine, on lemborexant pharmacokinetics was evaluated in a Phase 1 study. Additionally, post hoc analysis of dat...

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Detalles Bibliográficos
Autores principales: Landry, Ishani, Aluri, Jagadeesh, Hall, Nancy, Kumar, Dinesh, Dayal, Satish, Moline, Margaret, Reyderman, Larisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604696/
https://www.ncbi.nlm.nih.gov/pubmed/33135390
http://dx.doi.org/10.1002/prp2.678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604696/
https://www.ncbi.nlm.nih.gov/pubmed/33135390
http://dx.doi.org/10.1002/prp2.678

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