Cargando…

Overexpression of RNF126 Promotes the Development of Colorectal Cancer via Enhancing p53 Ubiquitination and Degradation

BACKGROUND: RING finger protein 126 (RNF126), as a novel E3 ubiquitin ligase, plays an oncogenic role in several solid cancers. But its potential role in colorectal cancer (CRC) that harbored 50% mutant p53, to our knowledge, is rarely reported. MATERIALS AND METHODS: We investigated the clinical si...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Shiyang, Wang, Tianlong, Wang, Li, Zhong, Liansheng, Li, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604871/ https://www.ncbi.nlm.nih.gov/pubmed/33149608 http://dx.doi.org/10.2147/OTT.S271855

Ejemplares similares

Overexpression of RNF126 Promotes the Development of Colorectal Cancer via Enhancing p53 Ubiquitination and Degradation [Corrigendum]
Publicado: (2021)

E3 Ubiquitin ligase RNF126 regulates the progression of tongue cancer
por: Wang, Lina, et al.
Publicado: (2016)

MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance
por: Zhou, Shan, et al.
Publicado: (2018)

RNF126 Quenches RNF168 Function in the DNA Damage Response
por: Zhang, Lianzhong, et al.
Publicado: (2018)

E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia
por: Benini, Monica, et al.
Publicado: (2017)

Ubiquitin ligase RNF125 targets PD-L1 for ubiquitination and degradation
por: Wei, Meng, et al.
Publicado: (2022)

Retraction Note: MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance
por: Zhou, Shan, et al.
Publicado: (2021)

Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma
por: Peng, Rui, et al.
Publicado: (2019)

E3 ubiquitin ligase RNF126 affects bladder cancer progression through regulation of PTEN stability
por: Xu, Huimin, et al.
Publicado: (2021)

Ring finger protein 126 (RNF126) suppresses ionizing radiation–induced p53-binding protein 1 (53BP1) focus formation
por: Lee, Nam Soo, et al.
Publicado: (2018)

RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation
por: Li, Tingting, et al.
Publicado: (2021)

RNF126‐Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple‐Negative Breast Cancer to Radiotherapy
por: Liu, Wenjing, et al.
Publicado: (2022)

RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1
por: Huang, Yajuan, et al.
Publicado: (2022)

RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1
por: Huang, Yajuan, et al.
Publicado: (2022)

A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase
por: Ruan, Jingjing, et al.
Publicado: (2022)

RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression
por: Wang, Ying, et al.
Publicado: (2015)

RNF180 Inhibits Proliferation and Promotes Apoptosis of Colorectal Cancer Through Ubiquitination of WISP1
por: Wei, Feng, et al.
Publicado: (2021)

RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation
por: Jiang, Li, et al.
Publicado: (2021)

PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53
por: Wang, Wuyi, et al.
Publicado: (2021)

RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment
por: Kongsema, M, et al.
Publicado: (2016)

RNF157 attenuates CD4(+) T cell-mediated autoimmune response by promoting HDAC1 ubiquitination and degradation
por: Wang, Peng, et al.
Publicado: (2023)

Structural and functional insights into the E3 ligase, RNF126
por: Krysztofinska, Ewelina M., et al.
Publicado: (2016)

Regulation of P53 signaling in breast cancer by the E3 ubiquitin ligase RNF187
por: Li, Xin, et al.
Publicado: (2022)

RNF126, 168 and CUL1: The Potential Utilization of Multi-Functional E3 Ubiquitin Ligases in Genome Maintenance for Cancer Therapy
por: Chang, Hae Ryung
Publicado: (2023)

RNF2 inhibits E-Cadherin transcription to promote hepatocellular carcinoma metastasis via inducing histone mono-ubiquitination
por: Yao, Lei, et al.
Publicado: (2023)

RBCK1 promotes p53 degradation via ubiquitination in renal cell carcinoma
por: Yu, Sifan, et al.
Publicado: (2019)

The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function
por: Okamoto, Takumi, et al.
Publicado: (2020)

RNF11 at the Crossroads of Protein Ubiquitination
por: Mattioni, Anna, et al.
Publicado: (2020)

Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168
por: Kocyłowski, Maciej K, et al.
Publicado: (2015)

Ubiquitin-Like Protein UBD Promotes Cell Proliferation in Colorectal Cancer by Facilitating p53 Degradation
por: Su, Hongbin, et al.
Publicado: (2021)

NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A
por: Wu, Chenglei, et al.
Publicado: (2017)

MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance
por: Lu, Jinping, et al.
Publicado: (2018)

BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response
por: Zhao, Hongchang, et al.
Publicado: (2014)

The nucleoprotein of influenza A virus induces p53 signaling and apoptosis via attenuation of host ubiquitin ligase RNF43
por: Nailwal, H, et al.
Publicado: (2015)

RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations
por: Zhang, Hongxia, et al.
Publicado: (2023)

RNF141 interacts with KRAS to promote colorectal cancer progression
por: Zhang, Jiuna, et al.
Publicado: (2021)

Overexpression of OTU domain-containing ubiquitin aldehyde-binding protein 1 exacerbates colorectal cancer malignancy by inhibiting protein degradation of β-Catenin via Ubiquitin-proteasome pathway
por: Ye, Daoxiong, et al.
Publicado: (2022)

The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells
por: Schneider, Deborah, et al.
Publicado: (2019)

Retraction of “MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance”
por: Lu, Jinping, et al.
Publicado: (2021)

RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma
por: Lin, Cheng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uhpfnt628tjj5peuhrl0e8fkv9