Reconstructing double-stranded DNA fragments on a single-molecule level reveals patterns of degradation in ancient samples

Extensive manipulations involved in the preparation of DNA samples for sequencing have hitherto made it impossible to determine the precise structure of double-stranded DNA fragments being sequenced, such as the presence of blunt ends, single-stranded overhangs, or single-strand breaks. We here desc...

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Detalles Bibliográficos
Autores principales: Bokelmann, Lukas, Glocke, Isabelle, Meyer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605269/
https://www.ncbi.nlm.nih.gov/pubmed/32963029
http://dx.doi.org/10.1101/gr.263863.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605269/
https://www.ncbi.nlm.nih.gov/pubmed/32963029
http://dx.doi.org/10.1101/gr.263863.120

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