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Reconstructing double-stranded DNA fragments on a single-molecule level reveals patterns of degradation in ancient samples
Extensive manipulations involved in the preparation of DNA samples for sequencing have hitherto made it impossible to determine the precise structure of double-stranded DNA fragments being sequenced, such as the presence of blunt ends, single-stranded overhangs, or single-strand breaks. We here desc...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605269/ https://www.ncbi.nlm.nih.gov/pubmed/32963029 http://dx.doi.org/10.1101/gr.263863.120 |