Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a

[Image: see text] CRISPR-Cas12a is a genome-editing system, recently also harnessed for nucleic acid detection, which is promising for the diagnosis of the SARS-CoV-2 coronavirus through the DETECTR technology. Here, a collective ensemble of multimicrosecond molecular dynamics characterizes the key...

Descripción completa

Detalles Bibliográficos
Autores principales: Saha, Aakash, Arantes, Pablo R., Hsu, Rohaine V., Narkhede, Yogesh B., Jinek, Martin, Palermo, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605327/
https://www.ncbi.nlm.nih.gov/pubmed/33107304
http://dx.doi.org/10.1021/acs.jcim.0c00929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605327/
https://www.ncbi.nlm.nih.gov/pubmed/33107304
http://dx.doi.org/10.1021/acs.jcim.0c00929

Ejemplares similares