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Impact of Androgen Deprivation on Oxidative Stress and Antioxidant Status in Nigerian Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy

PURPOSE: Prostate cancer (CaP) incidence and mortality rate are increasing in Africa. Some have linked oxidative stress with the pathogenesis of cancer. This study assessed the levels of malondialdehyde (MDA), nitric oxide (NO), total plasma peroxide (TPP), and total antioxidant capacity (TAC) in Ni...

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Autores principales: Bassey, Iya Eze, Emodi, Bukola Abosede, Akpan, Uwem Okon, Iyakndue, Idorenyin Francesca Akpan, Anakebe, Edim Azubuike, Icha, Bassey Edward, Efobi, Henry Afamuefuna, Ntinya, Akan Joshua, Udoh, Alphonsus Ekpe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605378/
https://www.ncbi.nlm.nih.gov/pubmed/33001740
http://dx.doi.org/10.1200/GO.20.00290
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author Bassey, Iya Eze
Emodi, Bukola Abosede
Akpan, Uwem Okon
Iyakndue, Idorenyin Francesca Akpan
Anakebe, Edim Azubuike
Icha, Bassey Edward
Efobi, Henry Afamuefuna
Ntinya, Akan Joshua
Udoh, Alphonsus Ekpe
author_facet Bassey, Iya Eze
Emodi, Bukola Abosede
Akpan, Uwem Okon
Iyakndue, Idorenyin Francesca Akpan
Anakebe, Edim Azubuike
Icha, Bassey Edward
Efobi, Henry Afamuefuna
Ntinya, Akan Joshua
Udoh, Alphonsus Ekpe
author_sort Bassey, Iya Eze
collection PubMed
description PURPOSE: Prostate cancer (CaP) incidence and mortality rate are increasing in Africa. Some have linked oxidative stress with the pathogenesis of cancer. This study assessed the levels of malondialdehyde (MDA), nitric oxide (NO), total plasma peroxide (TPP), and total antioxidant capacity (TAC) in Nigerian patients with CaP. PATIENTS AND METHODS: One hundred twenty patients with CaP and 100 apparently healthy controls were consecutively recruited into this case-control study. The patients with CaP were divided into treatment-naïve and androgen deprivation therapy (ADT)–treated groups. Anthropometric indices were measured, and MDA, NO, TAC, and TPP were assayed by colorimetric methods. The t test and analysis of variance were used in analysis of data; statistical significance was set at P < .05, and 95% CIs were reported. RESULTS: The patients with CaP had significantly higher waist-hip ratios and NO (P = .0001), TPP (P = .001), oxidative stress index (OSI; P = .003), and MDA values (P = .002) than controls. The treatment-naive patients with CaP had significantly higher waist-hip ratios (P = .011) and TPP (P = .013), MDA (P = .011), and NO values (P = .0001) and lower TAC values (P = .013) compared with the controls. The ADT-treated patients had higher waist-hip ratios (P = .0001) and TPP (P = .005), OSI (P = .005), MDA (P = .011), and NO values (P = .0001) than the controls. However, the treatment-naive patients had significantly higher NO values (P = .05) only compared with the ADT-treated patients. There was a significantly positive correlation between MDA and duration of treatment (r = 0.280, P = .018) in ADT-treated patients with CaP. CONCLUSION: This study demonstrated that patients with CaP have higher levels of TPP, MDA, and NO and lower levels of TAC compared with men without CaP. In addition, even in patients with CaP undergoing treatment, TPP and MDA levels remained high.
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spelling pubmed-76053782020-11-09 Impact of Androgen Deprivation on Oxidative Stress and Antioxidant Status in Nigerian Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy Bassey, Iya Eze Emodi, Bukola Abosede Akpan, Uwem Okon Iyakndue, Idorenyin Francesca Akpan Anakebe, Edim Azubuike Icha, Bassey Edward Efobi, Henry Afamuefuna Ntinya, Akan Joshua Udoh, Alphonsus Ekpe JCO Glob Oncol ORIGINAL REPORTS PURPOSE: Prostate cancer (CaP) incidence and mortality rate are increasing in Africa. Some have linked oxidative stress with the pathogenesis of cancer. This study assessed the levels of malondialdehyde (MDA), nitric oxide (NO), total plasma peroxide (TPP), and total antioxidant capacity (TAC) in Nigerian patients with CaP. PATIENTS AND METHODS: One hundred twenty patients with CaP and 100 apparently healthy controls were consecutively recruited into this case-control study. The patients with CaP were divided into treatment-naïve and androgen deprivation therapy (ADT)–treated groups. Anthropometric indices were measured, and MDA, NO, TAC, and TPP were assayed by colorimetric methods. The t test and analysis of variance were used in analysis of data; statistical significance was set at P < .05, and 95% CIs were reported. RESULTS: The patients with CaP had significantly higher waist-hip ratios and NO (P = .0001), TPP (P = .001), oxidative stress index (OSI; P = .003), and MDA values (P = .002) than controls. The treatment-naive patients with CaP had significantly higher waist-hip ratios (P = .011) and TPP (P = .013), MDA (P = .011), and NO values (P = .0001) and lower TAC values (P = .013) compared with the controls. The ADT-treated patients had higher waist-hip ratios (P = .0001) and TPP (P = .005), OSI (P = .005), MDA (P = .011), and NO values (P = .0001) than the controls. However, the treatment-naive patients had significantly higher NO values (P = .05) only compared with the ADT-treated patients. There was a significantly positive correlation between MDA and duration of treatment (r = 0.280, P = .018) in ADT-treated patients with CaP. CONCLUSION: This study demonstrated that patients with CaP have higher levels of TPP, MDA, and NO and lower levels of TAC compared with men without CaP. In addition, even in patients with CaP undergoing treatment, TPP and MDA levels remained high. American Society of Clinical Oncology 2020-10-01 /pmc/articles/PMC7605378/ /pubmed/33001740 http://dx.doi.org/10.1200/GO.20.00290 Text en © 2020 by American Society of Clinical Oncology https://creativecommons.org/licenses/by/4.0/ Licensed under the Creative Commons Attribution 4.0 License: https://creativecommons.org/licenses/by/4.0/
spellingShingle ORIGINAL REPORTS
Bassey, Iya Eze
Emodi, Bukola Abosede
Akpan, Uwem Okon
Iyakndue, Idorenyin Francesca Akpan
Anakebe, Edim Azubuike
Icha, Bassey Edward
Efobi, Henry Afamuefuna
Ntinya, Akan Joshua
Udoh, Alphonsus Ekpe
Impact of Androgen Deprivation on Oxidative Stress and Antioxidant Status in Nigerian Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy
title Impact of Androgen Deprivation on Oxidative Stress and Antioxidant Status in Nigerian Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy
title_full Impact of Androgen Deprivation on Oxidative Stress and Antioxidant Status in Nigerian Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy
title_fullStr Impact of Androgen Deprivation on Oxidative Stress and Antioxidant Status in Nigerian Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy
title_full_unstemmed Impact of Androgen Deprivation on Oxidative Stress and Antioxidant Status in Nigerian Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy
title_short Impact of Androgen Deprivation on Oxidative Stress and Antioxidant Status in Nigerian Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy
title_sort impact of androgen deprivation on oxidative stress and antioxidant status in nigerian patients with prostate cancer undergoing androgen deprivation therapy
topic ORIGINAL REPORTS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605378/
https://www.ncbi.nlm.nih.gov/pubmed/33001740
http://dx.doi.org/10.1200/GO.20.00290
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