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LHX6 Affects Erlotinib Resistance and Migration of EGFR-Mutant Non-Small-Cell Lung Cancer HCC827 Cells Through Suppressing Wnt/β-Catenin Signaling

BACKGROUND: miR-214 has been reported to contribute to erlotinib resistance in non-small-cell lung cancer (NSCLC) through targeting LHX6; however, the molecular mechanisms underlying the involvement of LHX6 in mediating the resistance to EGFR-TKIs in erlotinib-resistant NSCLC HCC827 (HCC827/ER) cell...

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Detalles Bibliográficos
Autores principales: Wang, Qiang, Liao, Jinrong, He, Zhiyong, Su, Ying, Lin, Dong, Xu, Ling, Xu, Haipeng, Lin, Jinghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605383/
https://www.ncbi.nlm.nih.gov/pubmed/33149613
http://dx.doi.org/10.2147/OTT.S258896