Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort

PURPOSE: We evaluated the performance of the recently extended Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a Dutch prospective cohort, using a polygenic risk score (PRS) based on 313 breast cancer (BC)–associated variants (PRS(313)) and o...

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Detalles Bibliográficos
Autores principales: Lakeman, Inge M. M., Rodríguez-Girondo, Mar, Lee, Andrew, Ruiter, Rikje, Stricker, Bruno H., Wijnant, Sara R. A., Kavousi, Maryam, Antoniou, Antonis C., Schmidt, Marjanka K., Uitterlinden, André G., van Rooij, Jeroen, Devilee, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605432/
https://www.ncbi.nlm.nih.gov/pubmed/32624571
http://dx.doi.org/10.1038/s41436-020-0884-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605432/
https://www.ncbi.nlm.nih.gov/pubmed/32624571
http://dx.doi.org/10.1038/s41436-020-0884-4

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