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Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation
Although congenital heart defects (CHDs) represent the most common birth defect, a comprehensive understanding of disease etiology remains unknown. This is further complicated since CHDs can occur in isolation or as a feature of another disorder. Analyzing disorders with associated CHDs provides a p...
Autores principales: | Lu, Po-Nien, Moreland, Trevor, Christian, Courtney J., Lund, Troy C., Steet, Richard A., Flanagan-Steet, Heather |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605527/ https://www.ncbi.nlm.nih.gov/pubmed/33055423 http://dx.doi.org/10.1172/jci.insight.133019 |
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