Inhibition of TRPV1 by SHP-1 in nociceptive primary sensory neurons is critical in PD-L1 analgesia

Recently programmed death-ligand 1 (PD-L1) receptor PD-1 was found in dorsal root ganglion (DRG) neurons, and PD-L1 activates PD-1 to inhibit inflammatory and neuropathic pain by modulating neuronal excitability. However, the downstream signaling of PD-1 in sensory neurons remains unclear. Here, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Ben-Long, Cao, Qi-Lai, Zhao, Xin, Liu, Hui-Zhu, Zhang, Yu-Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605531/
https://www.ncbi.nlm.nih.gov/pubmed/32960817
http://dx.doi.org/10.1172/jci.insight.137386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605531/
https://www.ncbi.nlm.nih.gov/pubmed/32960817
http://dx.doi.org/10.1172/jci.insight.137386

Ejemplares similares