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IL-4Rα signaling in CD4(+)CD25(+)FoxP3(+) T regulatory cells restrains airway inflammation via limiting local tissue IL-33
Impaired tolerance to innocuous particles during allergic asthma has been linked to increased plasticity of FoxP3(+) regulatory T cells (Tregs) reprogramming into pathogenic effector cells, thus exacerbating airway disease. However, failure of tolerance mechanisms is driven by Th2 inflammatory signa...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605533/ https://www.ncbi.nlm.nih.gov/pubmed/32931477 http://dx.doi.org/10.1172/jci.insight.136206 |