Serum amyloid A–containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties

The ability of HDL to inhibit inflammation in adipocytes and adipose tissue is reduced when HDL contains serum amyloid A (SAA) that is trapped by proteoglycans at the adipocyte surface. Because we recently found that the major extracellular matrix proteoglycan produced by hypertrophic adipocytes is...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Chang Yeop, Kang, Inkyung, Omer, Mohamed, Wang, Shari, Wietecha, Tomasz, Wight, Thomas N., Chait, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605543/
https://www.ncbi.nlm.nih.gov/pubmed/32970631
http://dx.doi.org/10.1172/jci.insight.142635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605543/
https://www.ncbi.nlm.nih.gov/pubmed/32970631
http://dx.doi.org/10.1172/jci.insight.142635

Ejemplares similares