Cargando…

Mechanism of ligand recognition by human ACE2 receptor

Angiotensin converting enzyme 2 (ACE2) plays a key role in renin-angiotensin system regulation and amino acid homeostasis. Human ACE2 acts as the receptor for severe acute respiratory syndrome coronaviruses SARS-CoV and SARS-CoV-2. ACE2 is also widely expressed in epithelial cells of lungs, heart, k...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhattarai, Apurba, Pawnikar, Shristi, Miao, Yinglong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605550/ https://www.ncbi.nlm.nih.gov/pubmed/33140043 http://dx.doi.org/10.1101/2020.10.30.362749

Ejemplares similares

Mechanism and Pathways of Inhibitor Binding to the Human ACE2 Receptor for SARS-CoV1/2
por: Bhattarai, Apurba, et al.
Publicado: (2021)

Binding Analysis Using Accelerated Molecular Dynamics Simulations and Future Perspectives
por: Pawnikar, Shristi, et al.
Publicado: (2022)

Mechanism of Peptide Agonist Binding in CXCR4 Chemokine Receptor
por: Pawnikar, Shristi, et al.
Publicado: (2022)

Mechanism of tethered agonist-mediated signaling by polycystin-1
por: Pawnikar, Shristi, et al.
Publicado: (2022)

Challenges and frontiers of computational modelling of biomolecular recognition
por: Wang, Jinan, et al.
Publicado: (2022)

Efficient purification and assembly of ribonucleoprotein complex for interaction analysis by MST assay coupled with GaMD simulations
por: Gao, Yunrong, et al.
Publicado: (2021)

Mechanisms of γ-Secretase Activation and Substrate Processing
por: Bhattarai, Apurba, et al.
Publicado: (2020)

Molecular Simulations and Drug Discovery of Adenosine Receptors
por: Wang, Jinan, et al.
Publicado: (2022)

Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A(1) Receptor
por: Miao, Yinglong, et al.
Publicado: (2018)

Mechanism for Multiple Ligand Recognition by the Human Transferrin Receptor
por: Giannetti, Anthony M, et al.
Publicado: (2003)

ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV
por: Lubbe, Lizelle, et al.
Publicado: (2020)

Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein
por: Do, Hung N., et al.
Publicado: (2023)

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2
por: Xu, Yingna, et al.
Publicado: (2022)

Pathways and Mechanism of Caffeine Binding to Human Adenosine A(2A) Receptor
por: Do, Hung N., et al.
Publicado: (2021)

The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition
por: He, Hui-Qiong, et al.
Publicado: (2017)

Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)
por: Chen, Yan, et al.
Publicado: (2023)

Mechanism of RNA recognition by a Musashi RNA-binding protein
por: Wang, Jinan, et al.
Publicado: (2021)

Structural basis for the activation and ligand recognition of the human oxytocin receptor
por: Waltenspühl, Yann, et al.
Publicado: (2022)

ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa
por: Ramal-Sanchez, Marina, et al.
Publicado: (2022)

Ligand recognition and activation of neuromedin U receptor 2
por: Zhao, Wenli, et al.
Publicado: (2022)

Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel
por: Huang, Yihe, et al.
Publicado: (2019)

Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2
por: Wang, Xi, et al.
Publicado: (2021)

Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2
por: Pan, Xin, et al.
Publicado: (2023)

Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion
por: Trevor, Camilla E., et al.
Publicado: (2019)

Structural basis for ligand recognition at the human MT(1) melatonin receptor
por: Stauch, Benjamin, et al.
Publicado: (2019)

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
por: Yan, Renhong, et al.
Publicado: (2020)

Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7
por: Jaeger, Kathrin, et al.
Publicado: (2019)

Structural insights on ligand recognition at the human leukotriene B4 receptor 1
por: Michaelian, Nairie, et al.
Publicado: (2021)

Ligand recognition and G protein coupling of the human itch receptor MRGPRX1
por: Guo, Lulu, et al.
Publicado: (2023)

Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B(0)AT1 and ACE2-SIT1
por: Li, Yaning, et al.
Publicado: (2023)

Pattern recognition receptor ligand-induced differentiation of human transitional B cells
por: McMillan, Jourdan K. P., et al.
Publicado: (2022)

Structural basis for ligand recognition of the neuropeptide Y Y(2) receptor
por: Tang, Tingting, et al.
Publicado: (2021)

Editorial: Mechanisms, thermodynamics and kinetics of ligand binding revealed from molecular simulations and machine learning
por: Miao, Yinglong, et al.
Publicado: (2023)

Structural basis for σ(1) receptor ligand recognition
por: Schmidt, Hayden R., et al.
Publicado: (2018)

Nanoparticle-Based Receptors Mimic Protein-Ligand Recognition
por: Riccardi, Laura, et al.
Publicado: (2017)

Structural insights into ligand recognition and selectivity of somatostatin receptors
por: Zhao, Wenli, et al.
Publicado: (2022)

Expression of the COVID‐19 receptor ACE2 in the human conjunctiva
por: Lange, Clemens, et al.
Publicado: (2020)

Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein
por: Heinzelman, Pete, et al.
Publicado: (2020)

Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein
por: Heinzelman, Pete, et al.
Publicado: (2021)

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics
por: Barton, Michael I, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v9dsqi3dos9d8r9k2f4j5bm15f