ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease

Activation of the RIG-I-like receptors, RIG-I and MDA5, establishes an antiviral state by upregulating interferon (IFN)-stimulated genes (ISGs). Among these is ISG15 whose mechanistic roles in innate immunity still remain enigmatic. Here we report that ISGylation is essential for antiviral IFN respo...

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Detalles Bibliográficos
Autores principales: Liu, GuanQun, Lee, Jung-Hyun, Parker, Zachary M., Acharya, Dhiraj, Chiang, Jessica J., van Gent, Michiel, Riedl, William, Davis-Gardner, Meredith E., Wies, Effi, Chiang, Cindy, Gack, Michaela U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605552/
https://www.ncbi.nlm.nih.gov/pubmed/33140045
http://dx.doi.org/10.1101/2020.10.26.356048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605552/
https://www.ncbi.nlm.nih.gov/pubmed/33140045
http://dx.doi.org/10.1101/2020.10.26.356048

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