Boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against coronaviruses in cell culture

As the COVID-19 pandemic continues to fold out, the morbidity and mortality are increasing daily. Effective treatment for SARS-CoV-2 is urgently needed. We recently discovered four SARS-CoV-2 main protease (M(pro)) inhibitors including boceprevir, calpain inhibitors II and XII and GC-376 with potent...

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Detalles Bibliográficos
Autores principales: Hu, Yanmei, Ma, Chunlong, Szeto, Tommy, Hurst, Brett, Tarbet, Bart, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605558/
https://www.ncbi.nlm.nih.gov/pubmed/33140049
http://dx.doi.org/10.1101/2020.10.30.362335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605558/
https://www.ncbi.nlm.nih.gov/pubmed/33140049
http://dx.doi.org/10.1101/2020.10.30.362335

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