The HSP90 Inhibitor, 17-AAG, Influences the Activation and Proliferation of T Lymphocytes via AKT/GSK3β Signaling in MRL/lpr Mice

OBJECTIVE: To explore the molecular mechanism of 17-AAG in the treatment of systemic lupus erythematosus (SLE), and the effects of the heat shock protein 90 (HSP90) inhibitor 17-AAG on the activation and proliferation of lymphocytes and the AKT/GSK3β signaling pathway in MRL/lpr mice were detected....

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Detalles Bibliográficos
Autores principales: Hong, Liang-Jian, Chen, Ai-Jun, Li, Feng-Zeng, Chen, Ke-Jun, Fang, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605613/
https://www.ncbi.nlm.nih.gov/pubmed/33149557
http://dx.doi.org/10.2147/DDDT.S269725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605613/
https://www.ncbi.nlm.nih.gov/pubmed/33149557
http://dx.doi.org/10.2147/DDDT.S269725

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