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The HSP90 Inhibitor, 17-AAG, Influences the Activation and Proliferation of T Lymphocytes via AKT/GSK3β Signaling in MRL/lpr Mice
OBJECTIVE: To explore the molecular mechanism of 17-AAG in the treatment of systemic lupus erythematosus (SLE), and the effects of the heat shock protein 90 (HSP90) inhibitor 17-AAG on the activation and proliferation of lymphocytes and the AKT/GSK3β signaling pathway in MRL/lpr mice were detected....
Autores principales: | Hong, Liang-Jian, Chen, Ai-Jun, Li, Feng-Zeng, Chen, Ke-Jun, Fang, Sheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605613/ https://www.ncbi.nlm.nih.gov/pubmed/33149557 http://dx.doi.org/10.2147/DDDT.S269725 |
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