Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease

Drug-resistant mutations often have deleterious impacts on replication fitness, posing a fitness cost that can only be overcome by compensatory mutations. However, the role of fitness cost in the evolution of drug resistance has often been overlooked in clinical studies or in vitro selection experim...

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Detalles Bibliográficos
Autores principales: Zhang, Tian-hao, Dai, Lei, Barton, John P., Du, Yushen, Tan, Yuxiang, Pang, Wenwen, Chakraborty, Arup K., Lloyd-Smith, James O., Sun, Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605711/
https://www.ncbi.nlm.nih.gov/pubmed/33085662
http://dx.doi.org/10.1371/journal.pgen.1009009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605711/
https://www.ncbi.nlm.nih.gov/pubmed/33085662
http://dx.doi.org/10.1371/journal.pgen.1009009

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