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Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease
Drug-resistant mutations often have deleterious impacts on replication fitness, posing a fitness cost that can only be overcome by compensatory mutations. However, the role of fitness cost in the evolution of drug resistance has often been overlooked in clinical studies or in vitro selection experim...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605711/ https://www.ncbi.nlm.nih.gov/pubmed/33085662 http://dx.doi.org/10.1371/journal.pgen.1009009 |