Loss of the RNA trimethylguanosine cap is compatible with nuclear accumulation of spliceosomal snRNAs but not pre-mRNA splicing or snRNA processing during animal development

The 2,2,7-trimethylguanosine (TMG) cap is one of the first identified modifications on eukaryotic RNAs. TMG, synthesized by the conserved Tgs1 enzyme, is abundantly present on snRNAs essential for pre-mRNA splicing. Results from ex vivo experiments in vertebrate cells suggested that TMG ensures nucl...

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Detalles Bibliográficos
Autores principales: Cheng, Lin, Zhang, Yu, Zhang, Yi, Chen, Tao, Xu, Yong-Zhen, Rong, Yikang S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605716/
https://www.ncbi.nlm.nih.gov/pubmed/33085660
http://dx.doi.org/10.1371/journal.pgen.1009098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605716/
https://www.ncbi.nlm.nih.gov/pubmed/33085660
http://dx.doi.org/10.1371/journal.pgen.1009098

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