Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency

Mutations in the molecular co-chaperone Bcl2-associated athanogene 3 (BAG3) are found to cause dilated cardiomyopathy (DCM), resulting in systolic dysfunction and heart failure, as well as myofibrillar myopathy (MFM), which is characterized by protein aggregation and myofibrillar disintegration in s...

Descripción completa

Detalles Bibliográficos
Autores principales: Diofano, Federica, Weinmann, Karolina, Schneider, Isabelle, Thiessen, Kevin D., Rottbauer, Wolfgang, Just, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605898/
https://www.ncbi.nlm.nih.gov/pubmed/33137814
http://dx.doi.org/10.1371/journal.pgen.1009088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605898/
https://www.ncbi.nlm.nih.gov/pubmed/33137814
http://dx.doi.org/10.1371/journal.pgen.1009088

Ejemplares similares