An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline

Tauopathies including Alzheimer’s disease (AD) are marked by the accumulation of aberrantly modified tau proteins. Acetylated tau, in particular, has recently been implicated in neurodegeneration and cognitive decline. HDAC6 reversibly regulates tau acetylation, but its role in tauopathy progression...

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Detalles Bibliográficos
Autores principales: Trzeciakiewicz, Hanna, Ajit, Deepa, Tseng, Jui-Heng, Chen, Youjun, Ajit, Aditi, Tabassum, Zarin, Lobrovich, Rebecca, Peterson, Claire, Riddick, Natallia V., Itano, Michelle S., Tripathy, Ashutosh, Moy, Sheryl S., Lee, Virginia M. Y., Trojanowski, John Q., Irwin, David J., Cohen, Todd J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606452/
https://www.ncbi.nlm.nih.gov/pubmed/33139698
http://dx.doi.org/10.1038/s41467-020-19317-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606452/
https://www.ncbi.nlm.nih.gov/pubmed/33139698
http://dx.doi.org/10.1038/s41467-020-19317-4

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