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An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
Tauopathies including Alzheimer’s disease (AD) are marked by the accumulation of aberrantly modified tau proteins. Acetylated tau, in particular, has recently been implicated in neurodegeneration and cognitive decline. HDAC6 reversibly regulates tau acetylation, but its role in tauopathy progression...
Autores principales: | Trzeciakiewicz, Hanna, Ajit, Deepa, Tseng, Jui-Heng, Chen, Youjun, Ajit, Aditi, Tabassum, Zarin, Lobrovich, Rebecca, Peterson, Claire, Riddick, Natallia V., Itano, Michelle S., Tripathy, Ashutosh, Moy, Sheryl S., Lee, Virginia M. Y., Trojanowski, John Q., Irwin, David J., Cohen, Todd J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606452/ https://www.ncbi.nlm.nih.gov/pubmed/33139698 http://dx.doi.org/10.1038/s41467-020-19317-4 |
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