Modulating disease-relevant tau oligomeric strains by small molecules

The pathological aggregation of tau plays an important role in Alzheimer's disease and many other related neurodegenerative diseases, collectively referred to as tauopathies. Recent evidence has demonstrated that tau oligomers, small and soluble prefibrillar aggregates, are highly toxic due to...

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Detalles Bibliográficos
Autores principales: Lo Cascio, Filippa, Garcia, Stephanie, Montalbano, Mauro, Puangmalai, Nicha, McAllen, Salome, Pace, Andrea, Palumbo Piccionello, Antonio, Kayed, Rakez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606668/
https://www.ncbi.nlm.nih.gov/pubmed/32737202
http://dx.doi.org/10.1074/jbc.RA120.014630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606668/
https://www.ncbi.nlm.nih.gov/pubmed/32737202
http://dx.doi.org/10.1074/jbc.RA120.014630

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