Cargando…

Climbing fiber synapses rapidly and transiently inhibit neighboring Purkinje cells via ephaptic coupling

Climbing fibers (CFs) from the inferior olive (IO) make strong excitatory synapses onto cerebellar Purkinje cell (PC) dendrites, and trigger distinctive responses known as complex spikes (CSs). We find that in awake mice, a CS in one PC suppresses conventional simple spikes (SSs) in neighboring PCs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Kyung-Seok, Chen, Christopher H., Khan, Mehak M., Guo, Chong, Regehr, Wade G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606706/ https://www.ncbi.nlm.nih.gov/pubmed/32895566 http://dx.doi.org/10.1038/s41593-020-0701-z

Ejemplares similares

Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse
por: Weyrer, Christopher, et al.
Publicado: (2021)

Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions
por: Khan, Mehak M, et al.
Publicado: (2020)

Basket to Purkinje Cell Inhibitory Ephaptic Coupling Is Abolished in Episodic Ataxia Type 1
por: Martin, Henry G. S., et al.
Publicado: (2023)

Climbing Fiber Coupling between Adjacent Purkinje Cell Dendrites in Vivo
por: Bengtsson, Fredrik, et al.
Publicado: (2009)

Using ephaptic coupling to estimate the synaptic cleft resistivity of the calyx of Held synapse
por: Sierksma, Martijn C., et al.
Publicado: (2021)

Developmental Rewiring between Cerebellar Climbing Fibers and Purkinje Cells Begins with Positive Feedback Synapse Addition
por: Wilson, Alyssa Michelle, et al.
Publicado: (2019)

PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum
por: Okuno, Yuto, et al.
Publicado: (2023)

Realistic modeling of mesoscopic ephaptic coupling in the human brain
por: Ruffini, Giulio, et al.
Publicado: (2020)

Tortuous Cardiac Intercalated Discs Modulate Ephaptic Coupling
por: Ivanovic, Ena, et al.
Publicado: (2022)

In vivo ephaptic coupling allows memory network formation
por: Pinotsis, Dimitris A, et al.
Publicado: (2023)

C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity
por: Aimi, Takahiro, et al.
Publicado: (2023)

Purkinje cell stripes and long-term depression at the parallel fiber-Purkinje cell synapse
por: Hawkes, Richard
Publicado: (2014)

Beyond “all-or-nothing” climbing fibers: graded representation of teaching signals in Purkinje cells
por: Najafi, Farzaneh, et al.
Publicado: (2013)

Ephaptic communication in the vertebrate retina
por: Vroman, Rozan, et al.
Publicado: (2013)

Modelling the effect of ephaptic coupling on spike propagation in peripheral nerve fibres
por: Schmidt, Helmut, et al.
Publicado: (2022)

Molecular mechanism of parallel fiber-Purkinje cell synapse formation
por: Mishina, Masayoshi, et al.
Publicado: (2012)

Modulation, Plasticity and Pathophysiology of the Parallel Fiber-Purkinje Cell Synapse
por: Hoxha, Eriola, et al.
Publicado: (2016)

Ephaptic Coupling Is a Mechanism of Conduction Reserve During Reduced Gap Junction Coupling
por: Lin, Joyce, et al.
Publicado: (2022)

Climbing-fiber induced state transitions in cerebellar Purkinje cells are controlled by synaptic conductance changes
por: Engbers, Jordan DT, et al.
Publicado: (2010)

Modified climbing fiber/Purkinje cell synaptic connectivity in the cerebellum of the neonatal phencyclidine model of schizophrenia
por: Veleanu, Maxime, et al.
Publicado: (2022)

Ephaptic entrainment in hybrid neuronal model
por: Cunha, Gabriel Moreno, et al.
Publicado: (2022)

Proteomic Studies of a Single CNS Synapse Type: The Parallel Fiber/Purkinje Cell Synapse
por: Selimi, Fekrije, et al.
Publicado: (2009)

Ephaptic coupling in white matter fibre bundles modulates axonal transmission delays
por: Schmidt, Helmut, et al.
Publicado: (2021)

Persistent Posttetanic Depression at Cerebellar Parallel Fiber to Purkinje Cell Synapses
por: Bergerot, Astrid, et al.
Publicado: (2013)

Mechanisms of Spontaneous Climbing Fiber Discharge-Evoked Pauses and Output Modulation of Cerebellar Purkinje Cell in Mice
por: Jin, Xian-Hua, et al.
Publicado: (2017)

Climbing Fiber Regulation of Spontaneous Purkinje Cell Activity and Cerebellum-Dependent Blink Responses(1,2,3)
por: Zucca, Riccardo, et al.
Publicado: (2016)

Direct translation of climbing fiber burst-mediated sensory coding into post-synaptic Purkinje cell dendritic calcium
por: Roh, Seung-Eon, et al.
Publicado: (2020)

Elimination of all redundant climbing fiber synapses requires granule cells in the postnatal cerebellum
por: Bailly, Yannick, et al.
Publicado: (2018)

Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex
por: Guo, Chong, et al.
Publicado: (2021)

E(L)FENN: A Generalized Platform for Modeling Ephaptic Coupling in Spiking Neuron Models
por: Shifman, Aaron R., et al.
Publicado: (2019)

Modelling the effects of ephaptic coupling on selectivity and response patterns during artificial stimulation of peripheral nerves
por: Capllonch-Juan, Miguel, et al.
Publicado: (2020)

Ephaptic synchronization as a mechanism for selective amplification of stimuli
por: Chawla, Aman, et al.
Publicado: (2014)

Electrophysiological damage to neuronal membrane alters ephaptic entrainment
por: Cunha, Gabriel Moreno, et al.
Publicado: (2023)

Activity-Dependent Gating of Calcium Spikes by A-type K+ Channels Controls Climbing Fiber Signaling in Purkinje Cell Dendrites
por: Otsu, Yo, et al.
Publicado: (2014)

Excitation-contraction coupling in cardiac Purkinje fibers. Effects of caffeine on the intracellular [Ca2+] transient, membrane currents, and contraction
Publicado: (1984)

Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje Cell – DCN Synapse
por: Gruver, Kim M., et al.
Publicado: (2019)

Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons
por: Zhang, Ye, et al.
Publicado: (2019)

A mathematical model of ephaptic interactions in neuronal fiber pathways: Could there be more than transmission along the tracts?
por: Sheheitli, Hiba, et al.
Publicado: (2020)

Your Synapse or Mine? Promiscuous Protein Exchanges between Neighboring Synapses
por: Chanut, Françoise
Publicado: (2006)

Excitation-contraction coupling in cardiac Purkinje fibers. Effects of cardiotonic steroids on the intracellular [Ca2+] transient, membrane potential, and contraction
Publicado: (1984)

Cannot write session to /tmp/vufind_sessions/sess_g75lupjhelmh1q7f0aeujcdrph