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MULTIFACETED ROLE OF BRANCHED-CHAIN AMINO ACID METABOLISM IN CANCER

Metabolic reprogramming fulfils increased nutrient demands and regulates numerous oncogenic processes in tumors, leading to tumor malignancy. Branched-chain amino acids (BCAAs, i.e., valine, leucine, and isoleucine) function as nitrogen donors to generate macromolecules such as nucleotides and are i...

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Detalles Bibliográficos
Autores principales: Peng, Hui, Wang, Yingfei, Luo, Weibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606751/
https://www.ncbi.nlm.nih.gov/pubmed/32978521
http://dx.doi.org/10.1038/s41388-020-01480-z