Enantioselective S−H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides

The first example of enantioselective S−H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95 % ee) and yields (up to 97 %) are achieved for 31 examples in S−H insertion reactions of aryl thiols and α‐carbonyl...

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Autores principales: Momo, Patrícia B., Leveille, Alexandria N., Farrar, Elliot H. E., Grayson, Matthew N., Mattson, Anita E., Burtoloso, Antonio C. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606806/
https://www.ncbi.nlm.nih.gov/pubmed/32352184
http://dx.doi.org/10.1002/anie.202005563
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author Momo, Patrícia B.
Leveille, Alexandria N.
Farrar, Elliot H. E.
Grayson, Matthew N.
Mattson, Anita E.
Burtoloso, Antonio C. B.
author_facet Momo, Patrícia B.
Leveille, Alexandria N.
Farrar, Elliot H. E.
Grayson, Matthew N.
Mattson, Anita E.
Burtoloso, Antonio C. B.
author_sort Momo, Patrícia B.
collection PubMed
description The first example of enantioselective S−H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95 % ee) and yields (up to 97 %) are achieved for 31 examples in S−H insertion reactions of aryl thiols and α‐carbonyl sulfoxonium ylides.
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spelling pubmed-76068062020-12-03 Enantioselective S−H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides Momo, Patrícia B. Leveille, Alexandria N. Farrar, Elliot H. E. Grayson, Matthew N. Mattson, Anita E. Burtoloso, Antonio C. B. Angew Chem Int Ed Engl Communications The first example of enantioselective S−H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95 % ee) and yields (up to 97 %) are achieved for 31 examples in S−H insertion reactions of aryl thiols and α‐carbonyl sulfoxonium ylides. John Wiley and Sons Inc. 2020-05-28 2020-09-01 /pmc/articles/PMC7606806/ /pubmed/32352184 http://dx.doi.org/10.1002/anie.202005563 Text en © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Momo, Patrícia B.
Leveille, Alexandria N.
Farrar, Elliot H. E.
Grayson, Matthew N.
Mattson, Anita E.
Burtoloso, Antonio C. B.
Enantioselective S−H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
title Enantioselective S−H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
title_full Enantioselective S−H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
title_fullStr Enantioselective S−H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
title_full_unstemmed Enantioselective S−H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
title_short Enantioselective S−H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
title_sort enantioselective s−h insertion reactions of α‐carbonyl sulfoxonium ylides
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606806/
https://www.ncbi.nlm.nih.gov/pubmed/32352184
http://dx.doi.org/10.1002/anie.202005563
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