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The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury
Sepsis is the major cause of acute kidney injury (AKI) associated with high mortality rates. Mitochondrial dysfunction contributes to the pathophysiology of septic AKI. Mitophagy is an important mitochondrial quality control mechanism that selectively eliminates damaged mitochondria, but its role an...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606859/ https://www.ncbi.nlm.nih.gov/pubmed/33137712 http://dx.doi.org/10.1016/j.redox.2020.101767 |