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Activation of autophagy during farnesyl pyrophosphate synthase inhibition is mediated through PI3K/AKT/mTOR signaling

OBJECTIVES: Autophagy is divided into three phases: autophagosome engulfment of intracellular organelles and proteins, autophagosome fusion with lysosomes, and autolysosome degradation. The farnesyl pyrophosphate synthase inhibitor ibandronate (IBAN) has in vivo cardioprotective properties, potentia...

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Detalles Bibliográficos
Autores principales:	Han, Jie, Huang, Chaoyang, Jiang, Jiukun, Jiang, Dongmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2019
Materias:	Pre-Clinical Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607048/ https://www.ncbi.nlm.nih.gov/pubmed/31884848 http://dx.doi.org/10.1177/0300060519875371

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