Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity

Piperine, a natural product derived from peppercorns, has a variety of biological activities that make it an attractive lead compound for medicinal chemistry. However, piperine has some problematic physicochemical properties including poor aqueous solubility and a susceptibility to UV-induced degrad...

Descripción completa

Detalles Bibliográficos
Autores principales: Lizarme-Salas, Yuvixza, Ariawan, Alexandra Daryl, Ratnayake, Ranjala, Luesch, Hendrik, Finch, Angela, Hunter, Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607426/
https://www.ncbi.nlm.nih.gov/pubmed/33178356
http://dx.doi.org/10.3762/bjoc.16.216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607426/
https://www.ncbi.nlm.nih.gov/pubmed/33178356
http://dx.doi.org/10.3762/bjoc.16.216

Ejemplares similares