Correcting for experiment-specific variability in expression compendia can remove underlying signals

MOTIVATION: In the past two decades, scientists in different laboratories have assayed gene expression from millions of samples. These experiments can be combined into compendia and analyzed collectively to extract novel biological patterns. Technical variability, or "batch effects," may r...

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Detalles Bibliográficos
Autores principales: Lee, Alexandra J, Park, YoSon, Doing, Georgia, Hogan, Deborah A, Greene, Casey S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607552/
https://www.ncbi.nlm.nih.gov/pubmed/33140829
http://dx.doi.org/10.1093/gigascience/giaa117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607552/
https://www.ncbi.nlm.nih.gov/pubmed/33140829
http://dx.doi.org/10.1093/gigascience/giaa117

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