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HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon

Here, we report our studies of immune-mediated regulation of Zika virus (ZIKV), herpes simplex virus 1 (HSV-1), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the human cornea. We find that ZIKV can be transmitted via corneal transplantation in mice. However, in human...

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Detalles Bibliográficos
Autores principales: Miner, Jonathan J., Platt, Derek J., Ghaznavi, Cyrus M., Chandra, Pallavi, Santeford, Andrea, Menos, Amber M., Dong, Zhenyu, Wang, Erin R., Qian, Wei, Karozichian, Elysse S., Philips, Jennifer A., Apte, Rajendra S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608022/
https://www.ncbi.nlm.nih.gov/pubmed/33147451
http://dx.doi.org/10.1016/j.celrep.2020.108339