Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system

Drug-evoked adaptations in the mesolimbic dopamine system are postulated to drive opioid abuse and addiction. These adaptations vary in magnitude and direction following different patterns of opioid exposure, but few studies have systematically manipulated the pattern of opioid administration while...

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Detalles Bibliográficos
Autores principales: Lefevre, Emilia M., Pisansky, Marc T., Toddes, Carlee, Baruffaldi, Federico, Pravetoni, Marco, Tian, Lin, Kono, Thomas J. Y., Rothwell, Patrick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608117/
https://www.ncbi.nlm.nih.gov/pubmed/32079024
http://dx.doi.org/10.1038/s41386-020-0643-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608117/
https://www.ncbi.nlm.nih.gov/pubmed/32079024
http://dx.doi.org/10.1038/s41386-020-0643-x

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