Activation of tyrosine phosphatase PTP1B in pyramidal neurons impairs endocannabinoid signaling by tyrosine receptor kinase trkB and causes schizophrenia-like behaviors in mice

Schizophrenia is a debilitating disorder affecting young adults displaying symptoms of cognitive impairment, anxiety, and early social isolation prior to episodes of auditory hallucinations. Cannabis use has been tied to schizophrenia-like symptoms, indicating that dysregulated endogenous cannabinoi...

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Detalles Bibliográficos
Autores principales: Qin, Zhaohong, Zhang, Li, Cruz, Shelly A., Stewart, Alexandre F. R., Chen, Hsiao-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608138/
https://www.ncbi.nlm.nih.gov/pubmed/32610340
http://dx.doi.org/10.1038/s41386-020-0755-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608138/
https://www.ncbi.nlm.nih.gov/pubmed/32610340
http://dx.doi.org/10.1038/s41386-020-0755-3

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