The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L

Mitophagy is a degradative pathway that mediates the degradation of the entire mitochondria, and defects in this process are implicated in many diseases including cancer. In mammals, mitophagy is mediated by BNIP3L (also known as NIX) that is a dual regulator of mitochondrial turnover and programmed...

Descripción completa

Detalles Bibliográficos
Autores principales: Hao, Bing-bing, Li, Xiao-jing, Jia, Xing-long, Wang, Yu-xing, Zhai, Lin-hui, Li, Duan-zhuo, Liu, Jie, Zhang, Die, Chen, Yu-lu, Xu, Yong-hu, Lee, Sang-kyu, Xu, Guo-feng, Chen, Xiao-hua, Dang, Yong-jun, Liu, Bin, Tan, Min-jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608331/
https://www.ncbi.nlm.nih.gov/pubmed/32210356
http://dx.doi.org/10.1038/s41401-020-0367-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608331/
https://www.ncbi.nlm.nih.gov/pubmed/32210356
http://dx.doi.org/10.1038/s41401-020-0367-9

Ejemplares similares