Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance

Defects in apoptosis can promote tumorigenesis and impair responses of malignant B cells to chemotherapeutics. Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of proteins are key regulators of the intrinsic, mitochondrial apoptotic pathway. Overexpression of antiapoptotic BCL-2 family prote...

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Detalles Bibliográficos
Autores principales: Kapoor, Isha, Bodo, Juraj, Hill, Brian T., Hsi, Eric D., Almasan, Alexandru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608616/
https://www.ncbi.nlm.nih.gov/pubmed/33139702
http://dx.doi.org/10.1038/s41419-020-03144-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608616/
https://www.ncbi.nlm.nih.gov/pubmed/33139702
http://dx.doi.org/10.1038/s41419-020-03144-y

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