Pharmacokinetic–pharmacodynamic modelling of the hypoglycaemic effect of pulsatile administration of human insulin in rats

The relationship between the plasma insulin (INS) concentration–time course and plasma glucose concentration–time course during and after pulsatile INS administration to rats was characterized using a pharmacokinetic–pharmacodynamic (PK–PD) model. A total INS dose of 0.5 IU/kg was intravenously inje...

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Detalles Bibliográficos
Autores principales: Miyazaki, Makoto, Hayata, Mariko, Samukawa, Noriaki, Iwanaga, Kazunori, Nagai, Junya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608663/
https://www.ncbi.nlm.nih.gov/pubmed/33139788
http://dx.doi.org/10.1038/s41598-020-76007-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608663/
https://www.ncbi.nlm.nih.gov/pubmed/33139788
http://dx.doi.org/10.1038/s41598-020-76007-3

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