p53 directly represses human LINE1 transposons

p53 is a potent tumor suppressor and commonly mutated in human cancers. Recently, we demonstrated that p53 genes act to restrict retrotransposons in germline tissues of flies and fish but whether this activity is conserved in somatic human cells is not known. Here we show that p53 constitutively res...

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Detalles Bibliográficos
Autores principales: Tiwari, Bhavana, Jones, Amanda E., Caillet, Candace J., Das, Simanti, Royer, Stephanie K., Abrams, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608743/
https://www.ncbi.nlm.nih.gov/pubmed/33060137
http://dx.doi.org/10.1101/gad.343186.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608743/
https://www.ncbi.nlm.nih.gov/pubmed/33060137
http://dx.doi.org/10.1101/gad.343186.120

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