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Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for…
ERK5 is a protein kinase that also contains a nuclear localisation signal and a transcriptional transactivation domain. Inhibition of ERK5 has therapeutic potential in cancer and inflammation and this has prompted the development of ERK5 kinase inhibitors (ERK5i). However, few ERK5i programmes have...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609025/ https://www.ncbi.nlm.nih.gov/pubmed/32915196 http://dx.doi.org/10.1042/BST20190338 |