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Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for…

ERK5 is a protein kinase that also contains a nuclear localisation signal and a transcriptional transactivation domain. Inhibition of ERK5 has therapeutic potential in cancer and inflammation and this has prompted the development of ERK5 kinase inhibitors (ERK5i). However, few ERK5i programmes have...

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Detalles Bibliográficos
Autores principales: Cook, Simon J., Tucker, Julie A., Lochhead, Pamela A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609025/
https://www.ncbi.nlm.nih.gov/pubmed/32915196
http://dx.doi.org/10.1042/BST20190338