USP22 Protects Against Myocardial Ischemia–Reperfusion Injury via the SIRT1-p53/SLC7A11–Dependent Inhibition of Ferroptosis–Induced Cardiomyocyte Death

Myocardial ischemia–reperfusion (MI/R) injury is characterized by iron deposition and reactive oxygen species production, which can induce ferroptosis. Ferroptosis has also been proposed to promote cardiomyocyte death. The current study sought to define the mechanism governing cardiomyocyte death in...

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Detalles Bibliográficos
Autores principales: Ma, Shuxian, Sun, Linyan, Wu, Wenhao, Wu, Jiangli, Sun, Zhangnan, Ren, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609439/
https://www.ncbi.nlm.nih.gov/pubmed/33192549
http://dx.doi.org/10.3389/fphys.2020.551318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609439/
https://www.ncbi.nlm.nih.gov/pubmed/33192549
http://dx.doi.org/10.3389/fphys.2020.551318

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