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Unveiling Druggable Pockets by Site-Specific Protein Modification: Beyond Antibody-Drug Conjugates

Site-specific modification approaches have been extensively employed in the development of protein-based technologies. In this field, stability and activity integrity are the envisioned features of chemically modified proteins. These methods are especially used in the design of antibody-drug conjuga...

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Detalles Bibliográficos
Autores principales: Martínez, Dailén G., Hüttelmaier, Stefan, Bertoldo, Jean B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609475/
https://www.ncbi.nlm.nih.gov/pubmed/33195086
http://dx.doi.org/10.3389/fchem.2020.586942