TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading

Neurofibrillary tangles (NFTs) composed of hyperphosphorylated and misfolded tau protein are a pathological hallmark of Alzheimer’s disease and other tauopathy conditions. Tau is predominantly an intraneuronal protein but is also secreted in physiological and pathological conditions. The extracellul...

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Detalles Bibliográficos
Autores principales: Xu, Yin, Du, Shuqi, Marsh, Jacob A., Horie, Kanta, Sato, Chihiro, Ballabio, Andrea, Karch, Celeste M., Holtzman, David M., Zheng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609570/
https://www.ncbi.nlm.nih.gov/pubmed/32366951
http://dx.doi.org/10.1038/s41380-020-0738-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609570/
https://www.ncbi.nlm.nih.gov/pubmed/32366951
http://dx.doi.org/10.1038/s41380-020-0738-0

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