Targeting Therapeutic Antibodies to the CNS: a Comparative Study of Intrathecal, Intravenous, and Subcutaneous Anti-Nogo A Antibody Treatment after Stroke in Rats

Antibody-based therapeutics targeting CNS antigens emerge as promising treatments in neurology. However, access to the CNS is limited by the blood–brain barrier. We examined the effects of a neurite growth-enhancing anti-Nogo A antibody therapy following 3 routes of administration—intrathecal (i.t.)...

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Detalles Bibliográficos
Autores principales: Wahl, Anna-Sophia, Correa, Daphne, Imobersteg, Stefan, Maurer, Michael Andreas, Kaiser, Julia, Augath, Marc Aurel, Schwab, Martin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609675/
https://www.ncbi.nlm.nih.gov/pubmed/32378027
http://dx.doi.org/10.1007/s13311-020-00864-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609675/
https://www.ncbi.nlm.nih.gov/pubmed/32378027
http://dx.doi.org/10.1007/s13311-020-00864-z

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