Combined use of irinotecan and p53 activator enhances growth inhibition of mesothelioma cells

Malignant mesothelioma (MM) is an aggressive malignant neoplasm which rapidly invades pleural tissues and has a poor prognosis. Here, we explore enhancement of the effect of irinotecan [camptothecin‐11 (CPT‐11)] by the p53‐dependent induction of carboxylesterase 2 (CES2), a CPT‐11‐activating enzyme,...

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Detalles Bibliográficos
Autores principales: Han, Bo, Lee‐Okada, Hyeon‐Cheol, Ishimine, Momoko, Orita, Hajime, Nishikawa, Keiko, Takagaki, Tetsuya, Kajino, Kazunori, Yokomizo, Takehiko, Hino, Okio, Kobayashi, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609812/
https://www.ncbi.nlm.nih.gov/pubmed/32961616
http://dx.doi.org/10.1002/2211-5463.12985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609812/
https://www.ncbi.nlm.nih.gov/pubmed/32961616
http://dx.doi.org/10.1002/2211-5463.12985

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