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Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers

[Image: see text] Transient permeability enhancers (PEs), such as caprylate, caprate, and salcaprozate sodium (SNAC), improve the bioavailability of poorly permeable macromolecular drugs. However, the effects are variable across individuals and classes of macromolecular drugs and biologics. Here, we...

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Detalles Bibliográficos
Autores principales: Hossain, Shakhawath, Joyce, Paul, Parrow, Albin, Jõemetsa, Silver, Höök, Fredrik, Larsson, Per, Bergström, Christel A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610231/
https://www.ncbi.nlm.nih.gov/pubmed/32960068
http://dx.doi.org/10.1021/acs.molpharmaceut.0c00668