KEAP1 Mutations Drive Tumorigenesis by Suppressing SOX9 Ubiquitination and Degradation

The transcription factor SOX9 is frequently amplified in diverse advanced‐stage human tumors. Its stability has been shown to be tightly controlled by ubiquitination‐dependent proteasome degradation. However, the exact underlying molecular mechanisms remain unclear. This work reports that SOX9 prote...

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Detalles Bibliográficos
Autores principales: Shao, Na, Huang, Hong, Idris, Muhammad, Peng, Xu, Xu, Feng, Dong, Shiwu, Liu, Chungang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610265/
https://www.ncbi.nlm.nih.gov/pubmed/33173725
http://dx.doi.org/10.1002/advs.202001018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610265/
https://www.ncbi.nlm.nih.gov/pubmed/33173725
http://dx.doi.org/10.1002/advs.202001018

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